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Histone modifications and chromatin regulation
The Shi Laboratory investigates the dynamic epigenetic mechanisms that regulate chromatin and transcription in an effort to better understand how they impact cancer development.
VAI News
FEATURED PUBLICATIONS
Wan L et al. ENL links histone acetylation to oncogenic gene expression in AML. Nature
Wen H et al. ZMYND11 links histone H3.3 K36 trimethylation to transcription elongation and tumor suppression. Nature
Li Y et al. AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation. Cell
Join Our Team
The labs of Drs. Xiaobing Shi and Hong Wen are seeking to hire one research technician. The Shi Lab and the Wen Lab are among the leading groups in the study of epigenetic regulation of chromatin and transcription in normal and cancer development. Main techniques used in the lab include molecular and cellular biology, biochemistry and biophysics, genetic and genomics, mammalian cell culture and mouse modeling. The research technician will work with these two labs offering ample learning and growth opportunity. Learn more here.